姓名：康安
职称：副教授
E-mail：kanga@njucm.edu.cn；13655182169
主要研究方向：天然药物的体内代谢与分析；中药防治胃肠道疾病的机理研究
个人简介
博士、副教授、硕士生导师。2011年6月毕业于中国药科大学，获药学（药物代谢动力学）博士学位，同年9月来南京中医药大学药学院工作。近年来主持国家自然科学基金2项、江苏省自然科学基金1项，厅局级课题2项，国家重点实验开放课题2项，校级课题3项，企业委托课题数项；以第一作者或通讯作者发表SCI论文22篇、中文核心期刊论文14篇，获授权发明专利3项；获江苏省教育科学研究成果奖（高校自然科学类）三等奖（3/5）、中国中医药研究促进会科技进步奖三等奖（3/7）；为国家自然科学基金通讯评审专家、广东省和浙江省自然科学基金通讯评审专家，江苏省药理学会中药药理专业委员会委员，《南京中医药大学学报》和《药物评价研究》杂志青年编委。
承担的主要科研项目
1. 国家自然科学基金面上项目，82374135 “芩连药对”通过稳态调控肠道AHR-CYP1A/IL-22信号轴促溃疡性结肠炎黏膜损伤修复的机制研究，2024.1-2027.12，49万元
2. 国家自然科学基金项目青年基金，81202983，人参总皂苷胃肠道代谢处置差异表征及机制研究，2013.1-2015.12，23万元
3. 江苏省自然科学基金面上项目，BK20171491，基于AhR-CYP1A负反馈信号轴研究四君子汤调节肠黏膜免疫平衡机制，2017.07-2020.06，10万元
4. 江苏省中医药局科技项目，YB201809，参苓白术散调控短链脂肪酸合成代谢发挥肠黏膜屏障保护作用的机制研究，2018.07-2021.09，5万元
5. 江苏省高校自然科学基金，16KJB360005，基于短链脂肪酸合成调控的四君子汤抗肠黏膜炎机制研究，2016.08-2018.07，3万元
6. 企业委托项目，石丹颗粒在慢性萎缩性胃炎大鼠体内效应物质发现及其活性成分对胃类器官增值和分化的影响，2023/8-2025/12，主持，14万元
7. 企业委托项目，健肠1号方对IBS-D肠道5-HT影响及物质基础研究，2022/11-2024/12，主持，15万元
8. 企业委托项目，功能性消化不良大鼠模型建立与DLT药效评价，2021/09-2023/12，主持，15万元
代表性论文
1. Li Qin, Chen Zihan, Zhang Jianrong, Liu Li, Tang Dongxin, Li Liu, Zhang Jinge, Hu Cheng, Ma Jiayi, Cheng Haibo*, Kang An**, Sun Dongdong***. The colonic metabolism differences of main alkaloids innormal and colitis mice treated with Coptis chinensisFranch. and Sophora flavescens Ait. herbal pair using liquidchromatography-high resolution mass spectrometrymethod combined with chemometrics, Journal of Separation Science, 2023;46:2300094
2. Su Yan, Tao Lin, Zhang Xiaoli, Sheng Xianjie, Li qin, Fei Wenying, Yin tao, Kang An*, Aa Jiye**, Wang Guangji, Non-targeted characteristic filter analysis combined with in silico prediction strategies to identify the chemical components and in vivo metabolites of Dalitong Granules by UPLC-Q-TOF/MS/MS. Journal of Pharmaceutical and Biomedical Analysis, 2023; 222:115086
3. Song Mengmeng#, Xu Zhuicheng#, Han Sixuan, Sheng Xianjie, Chen Yan, Li Xinru, Su Yan, Li Qin, Shan Chenxiao, Xie Tong, Kang An*, Systematic Identification of the Main Constituents from Agrimonia pilosa Ledeb. and Their Metabolites in Rats using HPLC-Q-TOF-MS/MS, Planta Medical. 2022; 88: 1369–1383
4. Song Mengmeng#, Sheng Xianjie#, Zhang Jianrong, Li Xinru, Dai Qianyun, Chen Yan, Kang An*. Homeostatic regulation of the aryl hydrocarbon receptor-cytochrome P450 1a axis by Scutellaria baicalensis-Coptis chinensis herb pair and its main constituents. Journal of Ethnopharmacology, 2022; 297:115545.
5. Chen Yan#, Miao Zhiwei#, Sheng Xianjie, Li Xinru, Ma Jiayi, Xu Xiaomei, Li Hui**, Kang An*, Sesquiterpene lactones-rich fraction from Aucklandia lappa Decne. alleviates dextran sulfate sodium induced ulcerative colitis through co-regulating MAPK and Nrf2/Hmox-1 signaling pathway. Journal of Ethnopharmacology, 2022; 295:115401.
6. Kang An, Jiang Jialu, Li Qin, Sheng Xianjie, Chen Yan, Tan Jiani, Li Liu, Shen Weixing, Tang Dongxin, Cheng Haibo*, Sun Dongdong**, Characterization of the chemical constituents and in vivo metabolic profile of Scutellaria barbata D. Don by ultra high performance liquid chromatography with high-resolution mass spectrometry. Journal of Separation Science. 2022; 45(9):1600-1609.
7. Song Mengmeng, Sheng Xianjie, Ye Genyi, Xu Zhuicheng, Li Xinru, Xie Tong, Deng Haishan*, Kang An**, Selective enrichment of microbiota-derived tryptophan metabolites in mouse faeces based on molecularly imprinted solid-phase extraction for HPLC analysis. Journal of Pharmaceutical and Biomedical Analysis, 2022; 212:114641.
8. Tang Yuyin, Li Su, Hu Linyu, Sun Xuetong, Zhang Bei, Ji Wenwen, Ma Lijuan, Qian Wenhui, Kang An*, Zhu Dong**, Hybrid Poly(AMPS-CS)-Au Microneedle Arrays to Enrich Metabolites from Skin for Early Disease Diagnosis, Advanced Healthcare Materials, 2021; 10(19):e2100764.
9. Guo Sijia, Jiang Dongjing, Zhang Qiao, Zhang Yi, Yao Weifeng, Cao Yudan, Bao Beihua, Tang Yuping, Kang An*, Zhang Li*. Diverse role of gut microbiota on reduction of ascites and intestinal injury in malignant ascites effusion rats treated with Euphorbia kansui stir-fried with vinegar, Journal of Ethnopharmacology. 2021; 267:11348 9.
10. Kang An, Xie Tong, Zhu Dong, Shan Jinjun, Di Liuqing*, Zheng Xiao**, Suppressive Effect of Ginsenoside Rg3 against Lipopolysaccharide-Induced Depression-Like Behavior and Neuroinflammation in Mice, Journal of Agricultural and Food Chemistry, 2017; 65(32): 6861-6869.
获得奖项与荣誉
1. 2020，第十二届“挑战杯”中国大学生创业计划竞赛铜奖，指导教师，
2. 2018江苏省教育教学与研究成果奖（研究类）三等奖，3/5
其他成果
专利
1. 汪受传，康安，单进军，徐珊，狄留庆, 一种治疗小儿腹泻的中药组合物及其制备方法和应用，ZL201510052111.1
教材
1. 药物分析，中国中医药出版社，编委，2023
2. 仪器分析，科学出版社，编委，2019
