职称: 副主任药师,副研究员 E-mail: lygljhit@163.com
主要研究方向:心血管药物作用机制研究;心肌细胞损伤标志物研究;micRNA和LncRNA在心肌细胞缺血再灌注损伤中的机制研究;线粒体动力学及线粒体自噬在心肌细胞损伤中的作用及机制研究;大黄酸对糖尿病心肌病的保护作用机制研究。
个人简介
心血管内科副主任药师,副研究员,南京大学、南方医科大学及南京中医药大学硕士生导师,现为江苏省医学会心血管分会基础与临床药学组委员,入选江苏省第五期333工程第三层次培养对象,近年以一作及通讯发表SCI论文十余篇,申请国家级课题2项,江苏省六大人才1项。
承担的主要科研项目
1. 国家自然科学基金青年项目:mtDNA在糖尿病心肌细胞损伤中的作用及机制研究 项目批准号 81400238 2015.1-2017.12 23万(第一负责人)
2. 国家自然科学基金面上项目:大黄酸对胰岛β细胞Drp1-Pink1/Parki线粒体自噬通路的干预作用研究 项目批准号:81773963 2018.01-2021.12 55万(第一负责人)
3.大黄酸通过调节drp1诱导的线粒体自噬保护胰岛β细胞作用机制研究。WSN-093 江苏省六大人才项目 4万 2019.1-2021.12(第一负责人)
代表性论文
1. Jing Liu, Zhaohong Chen, Yujing Zhang, Mingchao Zhang, Xiaodong Zhu, Yun Fan, Shaolin Shi, Ke Zen, Zhihong Liu* Rhein protects pancreatic β cells from Drp1-mediated mitochondria dysfunction under hyperglycemia. Diabetes. 2013 Nov;62(11):3927-35. DOI: 10.2337/db13-0251.(IF:8.3)
2. Jing Liu, Ying Zou, Yi Tang, Mingming Xi, Liang Xie, Qigao Zhang, Jianbin Gong*. Circulating cell-free mitochondrial deoxyribonucleic acid is increased in coronary heart disease patients with diabetes mellitus. J Diabetes Investig. 2016, 7(1): 109-14. DOI: 10.1111/jdi.12366.
3. Liu J, Cai X, Xie L, Tang Y, Cheng J, Wang J, Wang L*, Gong J*. Circulating Cell Free Mitochondrial DNA is a biomarker in the development of Coronary Heart Disease in the patients with type 2 diabetes. Clin Lab. 2015; 61(7):661-7. DOI: 10.7754/clin.lab.2014.141132.
4. Liu J, Zou Y, Tang Y, Xi M, Xie L, Zhang Q, Gong J. Circulating cell-free mitochondrial deoxyribonucleic acid is increased in coronary heart disease patients with diabetes mellitus[J]. J Diabetes Investig. 2016, 7(1): 109-114. DOI: 10.1111/jdi.12366.
5. Xie L, Liu S, Cheng J, Wang L, Liu J*, Gong J*. Exogenous administration of mitochondrial DNA promotes ischemia reperfusion injury via TLR9-p38 MAPK pathway[J]. Regul Toxicol Pharmacol, . 2017, 89:148-154. DOI:10.1016/j.yrtph.2017.07.028(共通讯)
6. Zhang C, Tang Y, Li Y, Xie L, Zhuang W, Liu J*, Gong J*. Unfolded protein response plays a critical role in heart damage after myocardial ischemia/reperfusion in rats. PloS One. 2017, 12: e0179042. DOI:10.1371/journal.pone.0179042.(共通讯)
7. Chengcheng Zhang, Songqing He, Yanming Li, Feng Li, Zhengbing Liu, Jing Liu*, Jianbin Gon*. Bisoprolol protects myocardium cells against ischemia/reperfusion injury by attenuating unfolded protein response in rat. Sci Rep. 2017, 7(1): 11859. DOI: 10.1038/s41598-017-12366-8.
8. Jing Liu, Yanming Li, Yi Tang, Jinghua Cheng, Jing Wang, Jianhua Li, Xiaohua Ma, Wei Zhuang, Jianbin Gong*, Zhihong Liu* Rhein protects the myocardiac cells against hypoxia/reoxygention-induced injury by suppressing GSK3β activity. Phytomedicine. 51: 1-6. DOI: 10.1016/j.phymed.2018.06.029.
9. Liang Xie, Songqing He, Na Kong, Ying Zhu, Yi Tang, Jianhua Li, Zhengbing Liu, Jing Liu*, Jianbin Gong*. Cpg-ODN, TLR9 Agonist, Aggravates Myocardial Ischemia/ Reperfusion Injury by Activation of TLR9-P38 MAPK Signaling. Cell Physiol Biochem. 2018, 47(4): 1389-1398. DOI: 10.1159/000490828(共通讯)
10. Jing Wang, Jing Liu*, Liang Xie, Xiaomin Cai, Xiaohua Ma, Jianbin Gong* Bisoprolol, a β1 antagonist, protects myocardial cells from ischemia reperfusion injury via PI3K/AKT/GSK3β pathway. Fundam Clin Pharmacol. 2020, 34(6): 708-720. DOI: 10.1111/fcp.12562.
11. 姚道敏谢亮宫剑滨朱静刘晶* 基于生物信息学方法分析心肌梗死大鼠miRNA芯片.《中国药理学通报》 2021年37卷5期 673-680页
12. 柳丽,季凯琳,徐海玲,曹梦怡,苏丹,刘晶*. 雷公藤甲素对皮质酮诱导小鼠海马神经元细胞损伤的保护作用. 医学研究生学报. 2021;34(11):1138-1143