周桂生

时间:2024-07-18浏览:2190

职称:副教授       E-mail:zhouguisheng1@126.com       主要研究方向:中药药效物质基础和方药配伍关系研究


 

个人简介

2016年博士毕业于上海交通大学药学专业。2022年入选江苏省第333高层次人才层次培养对象。担任Food ChemistryAnalytica Chimica ActaJournal of EthnopharmacologyFrontiers in PharmacologyMicrochemical Journal, Industrial Crops and Products等多本学术期刊的特邀审稿人。主持与重点参加国家及省部级课题10余项。近年来,以第一/通讯作者发表学术论文30余篇,SCI收录25篇,h-index20。参与编写专著1部。

 

承担的主要科研项目

1. 国家自然基金面上项目,82074126,泻心汤调控肠源性SCFAs介导肠上皮细胞-Th细胞交互应答改善T2DM肠上皮紧密连接的作用机制,2021.01-2024.1256万元,参加

2. 国家自然基金面上项目,81973576,犀角地黄汤作用于急性脑出血p38MAPK信号通路的相须相使增效机制研究,2020.01-2023.1255万元,参加

3. 国家自然基金青年项目,81803699,基于--肠道菌群轴的银杏酮酯和多奈哌齐治疗阿尔茨海默病联用增效的作用机理研究,2019.01-2021.1221万元,主持

4. 国家自然基金面上项目,81873001,基于VEGF-A通路中PLCγ1-PI3K/AKT反馈机制的蒲黄炭化瘀止血炮制机理研究,2019.01-2022.1257万元,参加

5. 国家自然基金面上项目,81773882,当归系列药对在新生化颗粒中配伍作用的物质基础和分子机制研究,2018.01-2021.1255万元,参加

6. 江苏省自然科学基金项目,BK20171068,基于--肠道菌群轴的银杏酮酯配伍多奈哌齐抗阿尔茨海默病作用增强的机理研究,2017.07-2020.0720万元,主持

7. 江苏省自然科学基金项目,BK20171491,基于AHR-CYP1A负反馈信号研究四君子汤调节肠黏膜免疫平衡机制,2017.07-2020.0710万元,参加

8. 国家自然基金面上项目,81673588,从代谢角度发现罗汉果皂苷抗肥胖型2型糖尿病物质基础及作用机制,2017.01-2020.1262万元,参加

9. 江苏省中药资源和产业化协同创新中心第三批重点立项项目,012092002006-4,银杏落叶资源化利用和产业化研究,2016.10-2018.1230万元,主持

10. 国家自然基金面上项目,81473318,四君子汤多糖的肠道菌群介导免疫作用发挥机制及物质基础研究,2015.01-2018.1275万元,参加

 

代表性论文

1. Gui-Sheng Zhou, Jiawei Lu, Tingting Xu, Yan Lu, Wenjun Chen, Jue Wang, Mengying Ke, Qiuxiang Shen, Youjuan Zhu, Jinjun Shan*, Shijia Liu*, Clinical Lipidomics Analysis Reveals Biomarkers of Lipid Peroxidation in Serum from Patients with Rheumatoid Arthritis, Microchemical Journal, 2021, 169, 106607.(第一作者)

2. Hui Yan, Zong-Jin Pu, Zhen-Yu Zhang, Gui-Sheng Zhou*, Dong-Qian Zou, Sheng Guo, Chao Li, Zhi-Lai Zhan, Jin-Ao Duan*, Research on Biomarkers of Different Growth Periods and Different Drying Processes of Citrus wilsonii Tanaka Based on Plant Metabolomics, Frontiers in Plant Science, 2021, 12, 700367.(共同通讯作者)

3. Gui-Sheng Zhou*, Yichu Yuan, You Yin*, Yuping Tang, Renjie Xu, Yan Liu, Peidong Chen, Lian Yin, Jin-Ao Duan*, Hydrophilic Interaction Chromatography Combined with Ultrasound-assisted Ionic Liquid Dispersive Liquid–liquid Microextraction for Determination of Underivatized Neurotransmitters in Dementia Patients’ Urine Samples, Analytica Chimica Acta, 2020, 1107, 74-84.(第一作者)

4. Jing Zhang, Jun Wang, Gui-Sheng Zhou*, Yajie Tan, Huijuan Tao, Jiaqian Chen, Zongjin Pu, Jiayan Ma, Wen She, An Kang, Yue Zhu, Pei Liu, Zhenhua Zhu, Xu-Qin Shi, Yuping Tang*, Jin-Ao Duan, Studies of the Anti-amnesic Effects and Mechanisms of Single and Combined Use of Donepezil and Ginkgo Ketoester Tablet on Scopolamine-induced Memory Impairment in Mice, Oxidative Medicine and Cellular Longevity, 2019, 8636835.(共同通讯作者)

5. 张静, 史旭芹, 周桂生*, 谭亚杰, 陈嘉倩, 陶慧娟, 濮宗进, 刘培, 朱悦, 钱大玮, 唐于平*, 段金廒, 基于主成分分析和多指标综合指数法对银杏酮酯-多奈哌齐不同量比抗痴呆作用比较研究. 药学学报, 2019, 54, 660669.(共同通讯作者)

6. Gui-Sheng Zhou, Yulong Zhang, Yang Li, Mengyue Wang, Xiaobo Li*, The Metabolism of a Natural Product Mogroside V, in Normal and Type 2 Diabetic Rats, Journal of Chromatography B, 2018, 1079, 25-33.(第一作者)

7. Gui-Sheng Zhou, Ying Peng, Lijuan Zhao, Mengyue Wang, Xiaobo Li*, Biotransformation of Total Saponins in Siraitia Fructus by Human Intestinal Microbiota of Normal and Type 2 Diabetic Patients: Comprehensive Metabolite Identification and Metabolic Profile Elucidation Using LC-Q-TOF/MS, Journal of Agricultural and Food Chemistry, 2017, 65, 1518-1524.(第一作者)

8. Gui-Sheng Zhou, Mengyue Wang, Yang Li, Renjie Xu, Xiaobo Li*, Comprehensive Qualitative and Quantitative Analysis on 61 Characteristic Constituents from Siraitia Grosvenorii Using a Rapid and Sensitive Ultrahigh-pressure Liquid Chromatography with Time-of-ight Mass Spectrometry, Journal of Pharmaceutical and Biomedical Analysis, 2016, 125: 1-14.(第一作者)

9. Gui-Sheng Zhou, Lei Fu, Xiaobo Li*, Optimisation of Ultrasound-assisted Extraction Conditions for Maximal Recovery of Active Monacolins and Removal of Toxic Citrinin from Red Yeast Rice by a Full Factorial Design Coupled with Response Surface Methodology, Food Chemistry, 2015, 170: 186-192.(第一作者)

10. Gui-Sheng Zhou, Xin Yao, Yuping Tang*, Dawei Qian, Shulan Su, Li Zhang, Chun Jin, Yong Qin, Jin-ao Duan*, An Optimized Ultrasound-assisted Extraction and Simultaneous Quantification of 26 Characteristic Components with Four Structure Types in Functional Foods from Ginkgo Seeds, Food Chemistry, 2014, 158: 177-185.(第一作者)

 

其他成果

论著:《药对现代研究》编委