李晓曼
副教授
E-mail:lixm@njucm.edu.cn
主要研究方向:
中药复方及活性成分对肿瘤转移的影响及机制
个人简介

1.Xuan Jiang, Manli Wang, Guoliang Cui, Yuanyuan Wu, Zhonghong Wei, Suyun Yu, Aiyun Wang, Wei Zou, Yanhong Pan, Xiaoman Li*, Yin Lu*. Tetramethylpyrazine attenuates the cancer stem cell like-properties and doxorubicin resistance by targeting HMGCR in breast cancer, Phytomedicine, 2025, 136: 156344-156358. (共同通讯,中科院一区,IF 8.3)

2.Qi Jia, Yinyin Zhou, Li Song, Ximeng Shi, Xuan Jiang, Ruizhi Tao, Aiyun Wang, YuanyuanWu, Zhonghong Wei, Yinan Zhang*, Xiaoman Li*, Yin Lu*. Baicalin alleviates chronic stress-induced breast cancer metastasis via directly targeting β2-adrenergic receptor, Journal of Pharmaceutical Analysis, 2024, 14(7): 100934-100949. (共同通讯,中科院一区,IF 8.9)

3.Guoliang Cui, Manli Wang, Xiaofeng Li, Can Wang, Kinyu Shon, Zhiting Liu, Lang Ren, Xiaoxian Yang, Xiaoman Li*, Yuanyuan Wu*, Zhiguang Sun*.Berberine in combination with evodiamine ameliorates gastroesophageal reflux disease through TAS2R38/TRPV1-mediated regulation of MAPK/NF-κB signaling pathways and macrophage polarization.Phytomedicine, 2024, 135: 156251-156267. (共同通讯,中科院一区,IF 8.3)

4.Yichen Liu, Ying Chen, Qiong Zhao, Tianyuan Xie, Chenxi Xiang, Qianqian Guo, Wenzhou Zhang, Yi Zhou, Yin Yuan, Yuxin Zhang, Tao Xi, Xiaoman Li*, Lufeng Zheng*. A positive TGF‐β/miR‐9 regulatory loop promotes the expansion and activity of tumour‐initiating cells in breast cancer, British Journal of Pharmacology, 2023, 180(17): 2280-2297.  (共同通讯,中科院二区,IF 7.7)

5.Xiaoman Li*, Qi Jia*, Yinyin Zhou, Xuan Jiang, Li Song, Yuanyuan Wu, Aiyun Wang, WenxingChen, Shijun Wang, Yin Lu. Tanshinone IIA attenuates the stemness of breast cancer cells viatargeting the miR-125b/STARD13 axis, Experimental Hematology & Oncology, 2022, 11(1): 2-17. (共同一作,中科院一区,IF 13.5 )

6.Yue Yang*, Xiaoman Li*, Ting Wang, Qianqian Guo, Tao Xi, Lufeng Zheng. Emerging agentsthat target signaling pathways in cancer stem cells, Journal of Hematology & Oncology, 2020,13(1): 60-77. (共同一作,中科院一区,IF 40.4)

科研项目

1.国家自然科学基金委员会,面上项目,82574740,基于“NETs-BCSCs环路探究小柴胡汤抑制乳腺癌因郁致转移”的整合调控机制,主持,2026-01-01 2029-12-3149万元,在研

2.国家自然科学基金委员会, 青年科学基金项目(C类)[原青年科学基金项目], 81903857, 丹参酮类成分通过抑制miR-9/STARD13信号轴削弱乳腺癌干细胞样特性及化疗耐药的机制研究, 主持,2020-01-01 2022-12-31, 20万元, 结题

3.江苏省高等学校基础科学(自然科学)研究重大项目,24KJA360005,柴胡-黄芩药对协同抗慢性应激诱导的乳腺癌转移研究,主持,2024.7 2027.730万元,在研

4.江苏省中医药科技发展计划项目面上项目,MS2024009,柴胡-黄芩药对干预GRB2-AR协同抑制慢性应激诱导的乳腺癌转移的作用及机制研究,主持,2025.1 2027.1210万元,在研

5.横向课题:中药香薰治疗失眠的药效研究,主持,2025.7-2026.722万元,在研

代表性论文

1.Xuan Jiang, Manli Wang, Guoliang Cui, Yuanyuan Wu, Zhonghong Wei, Suyun Yu, Aiyun Wang, Wei Zou, Yanhong Pan, Xiaoman Li*, Yin Lu*. Tetramethylpyrazine attenuates the cancer stem cell like-properties and doxorubicin resistance by targeting HMGCR in breast cancer, Phytomedicine, 2025, 136: 156344-156358. (共同通讯,中科院一区,IF 8.3)

2.Qi Jia, Yinyin Zhou, Li Song, Ximeng Shi, Xuan Jiang, Ruizhi Tao, Aiyun Wang, YuanyuanWu, Zhonghong Wei, Yinan Zhang*, Xiaoman Li*, Yin Lu*. Baicalin alleviates chronic stress-induced breast cancer metastasis via directly targeting β2-adrenergic receptor, Journal of Pharmaceutical Analysis, 2024, 14(7): 100934-100949. (共同通讯,中科院一区,IF 8.9)

3.Guoliang Cui, Manli Wang, Xiaofeng Li, Can Wang, Kinyu Shon, Zhiting Liu, Lang Ren, Xiaoxian Yang, Xiaoman Li*, Yuanyuan Wu*, Zhiguang Sun*.Berberine in combination with evodiamine ameliorates gastroesophageal reflux disease through TAS2R38/TRPV1-mediated regulation of MAPK/NF-κB signaling pathways and macrophage polarization.Phytomedicine, 2024, 135: 156251-156267. (共同通讯,中科院一区,IF 8.3)

4.Yichen Liu, Ying Chen, Qiong Zhao, Tianyuan Xie, Chenxi Xiang, Qianqian Guo, Wenzhou Zhang, Yi Zhou, Yin Yuan, Yuxin Zhang, Tao Xi, Xiaoman Li*, Lufeng Zheng*. A positive TGF‐β/miR‐9 regulatory loop promotes the expansion and activity of tumour‐initiating cells in breast cancer, British Journal of Pharmacology, 2023, 180(17): 2280-2297.  (共同通讯,中科院二区,IF 7.7)

5.Xiaoman Li*, Qi Jia*, Yinyin Zhou, Xuan Jiang, Li Song, Yuanyuan Wu, Aiyun Wang, WenxingChen, Shijun Wang, Yin Lu. Tanshinone IIA attenuates the stemness of breast cancer cells viatargeting the miR-125b/STARD13 axis, Experimental Hematology & Oncology, 2022, 11(1): 2-17. (共同一作,中科院一区,IF 13.5 )

6.Yue Yang*, Xiaoman Li*, Ting Wang, Qianqian Guo, Tao Xi, Lufeng Zheng. Emerging agentsthat target signaling pathways in cancer stem cells, Journal of Hematology & Oncology, 2020,13(1): 60-77. (共同一作,中科院一区,IF 40.4)

获得奖项与荣誉
其他成果