董佳佳
副教授
E-mail:dongjiajia300512@njucm.edu.cn
主要研究方向:
中药炮制和药代动力学
个人简介

1.国家自然科学基金委员会,青年科学基金项目(C类)[原青年科学基金项目], 82104700,肝脏转运体介导的甘草酸体内系统暴露调控和药物相互作用机制研究, 2022/01-2024/, 30万元,结题;

2.江苏省卫生健康委科研指导性项目,Z2025066,基于多维度模型的OATP1B转运体介导甘草酸与DAAs药物相互作用机制及精准用药策略研究,2026/03-2029/02,主持,2万,在研;

3.江苏省卫生健康委,指导性项目, Z2020012,基于PK-PD及代谢组学的三七蒸制机理研究, 2021/01-2023/12, 2万元,结题,主持;

4.国家自然科学基金委员会,面上项目, 82274098,基于“细胞膜通透性-转运蛋白”的醋制增强莪术肝 靶向效应调控机制研究, 2023/01-2026/12, 52万元,在研,参与;

5.国家自然科学基金委员会,面上项目, 82274096,基于生栀子泻温邪实火、炒栀子清郁热与脓毒症双向免疫调节特点探索栀子炮制机理与合理用药, 2023/01-2026/12, 52万元,在研,参与;

6.国家自然科学基金委员会,面上项目, 82173975,基于整合证据链的郁金醋制增强疏肝止痛作用机制研究, 2022/01- 2025/12, 55万元,在研,参与

科研项目

1.国家自然科学基金委员会,青年科学基金项目(C类)[原青年科学基金项目], 82104700,肝脏转运体介导的甘草酸体内系统暴露调控和药物相互作用机制研究, 2022/01-2024/, 30万元,结题;

2.江苏省卫生健康委科研指导性项目,Z2025066,基于多维度模型的OATP1B转运体介导甘草酸与DAAs药物相互作用机制及精准用药策略研究,2026/03-2029/02,主持,2万,在研;

3.江苏省卫生健康委,指导性项目, Z2020012,基于PK-PD及代谢组学的三七蒸制机理研究, 2021/01-2023/12, 2万元,结题,主持;

4.国家自然科学基金委员会,面上项目, 82274098,基于“细胞膜通透性-转运蛋白”的醋制增强莪术肝 靶向效应调控机制研究, 2023/01-2026/12, 52万元,在研,参与;

5.国家自然科学基金委员会,面上项目, 82274096,基于生栀子泻温邪实火、炒栀子清郁热与脓毒症双向免疫调节特点探索栀子炮制机理与合理用药, 2023/01-2026/12, 52万元,在研,参与;

6.国家自然科学基金委员会,面上项目, 82173975,基于整合证据链的郁金醋制增强疏肝止痛作用机制研究, 2022/01- 2025/12, 55万元,在研,参与

代表性论文

[1] Jiajia Dong, OlajideE Olaleye, Rongrong Jiang, Jing Li, Chuang Lu, Feifei Du, Fang Xu, Junling Yang, Fengqing Wang, Wei-wei Jia*, Chuan Li*, Glycyrrhizin has a high likelihood to be a victim of drug-drug interactions mediated by hepatic organic anion-transporting polypeptide 1B1/1B3, British Journal of Pharmacology, 2018, 175(17): 3486-3503.

[2] Jiajia Dong, De Ji*, Lianlin Su, Fengyang Zhang, Huangjin Tong, Chunqin Mao and Tulin Lu*. A simplified LC−MS/MS approach for simultaneous quantification and pharmacokinetics of five compounds in rats following oral administration of Gastrodia elata extract. Journal of Analytical Science and Technology, 2020, 11:18: 1-9.

[3] Jiajia Dong*, Zhenzhen Yin, Lianlin Su, Mengting Yu, Meng Wang, Lin Li, Chunqin Mao, Tulin Lu*. Comparative pharmacokinetic analysis of raw and steamed Panax notoginseng roots in rats by UPLC-MS/MS for simultaneously quantifying seven saponins. Pharmaceutical Biology, 2021, 59(1): 653-661.

[4] Jiajia Dong*, Jiajing Zhong, Xiangnan Wang, Doudou Geng,Chunqin Mao,Zhipeng Chen,Tulin Lu*, In Vivo Evidence of Human Organic Anion Transporting Polypeptide (OATP) 1B1 and OATP1B3 Mediated Disposition of Glycyrrhizin and Its Drug-Drug Interactions in Humanized Mice, Phytotherapy Research, 2026, accepted.

[5] JunLan Lu, XueShan Zeng, Xin Zhou, JunLing Yang, LingLing Ren, XinYu Long, FengQing Wang, Olajide E. Olaleye, NanNan Tian, Ya-Xuan Zhu, JiaJia Dong*, WeiWei Jia* and Chuan Li*. Molecular basis underlying hepatobiliary and renal excretion of phenolic acids of salvia miltiorrhiza roots(Danshen). Front pharmacol. 2022, 13:911982.

[6] YueranWu, Xiangnan Wang, Zhenzhen Yin, Jiajia Dong*. Geotrichum candidum arthrospore cell wall particles as a novel carrier for curcumin encapsulation. Food Chem, 2023, 404: 134308.

[7] Jianlu Lv#, Xingyi Shen#, Xinya Shen, Shimei Zhao, Rui Xu1,, Qiuying  Yan, Jian Lu, Danyang Zhu, Yonghua Zhao, Jiajia Dong*, Jiaying Wang,Xu Shen, NPLC0393 from Gynostemma pentaphyllum ameliorates Alzheimer’s disease-like pathology in mice by targeting protein phosphatase magnesium‐dependent 1A phosphatase, Phytotherapy Research, 2023, 37(10): 4771-4790.

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