陈佩东

教授

E-mail：cpd@njucm.edu.cn

主要研究方向：

中药活性成分及炮制机制研究

个人简介

1.Mingliang Gao, Yuling Zha, Nian Sheng, Yudan Cao, Weifeng Yao, Beihua Bao, Mingqiu Shan, Fangfang Cheng, Sheng Yu, Yi Zhang, Ting Geng, Shengjin Liu, Hui Yan, Peidong Chen, Juanjuan Zhang, Li Zhang,Integrated transcriptomics and lipidomics reveals protective effect in vascular endothelial barrier of a polysaccharide from Typhae Pollen,International Journal of Biological Macromolecules,Volume 282, Part 2,2024,136817,（中科院一区，IF=7.70）

2. Gao M, Lan J, Zha Y, Yao W, Bao B, Shan M, Zhang F, Zhou G, Yu S, Cheng F, Cao Y, Yan H, Zhang L^*, Chen P^*. Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Int J Biol Macromol. 2022，S0141-8130(22)02231-0. doi: 10.1016/j.ijbiomac.2022.10.002. （中科院一区，IF=8.19）

3. Gao M, Lan J, Zhang Y, Yu S, Bao B, Yao W, Cao Y, Shan M, Cheng F, Zhang L^*, Chen P^*. Discovery of processing-associated Q-marker of carbonized traditional Chinese medicine: An integrated strategy of metabolomics, systems pharmacology and in vivo high-throughput screening model. Phytomedicine. 202,102:154152. doi: 10.1016/j.phymed.2022.154152. （中科院一区，IF=7.89）

4. Wei X, Gao M, Sheng N, Yao W, Bao B, Cheng F, Cao Y, Yan H, Zhang L, Shan M^*, Chen P^*. Mechanism investigation of Shi-Xiao-San in treating blood stasis syndrome based on network pharmacology, molecular docking and in vitro/vivo pharmacological validation. J Ethnopharmacol. 2022,301:115746. doi: 10.1016/j.jep.2022.115746. （中科院二区，IF=5.39）

5.Gao M^#, Ge Z, Deng R, Bao B, Yao W, Cao Y, Shan M, Cheng F, Yan H, Chen P*, Zhang L^*. Evaluation of VEGF mediated pro-angiogenic and hemostatic effects and chemical marker investigation for Typhae Pollen and its processed product.J Ethnopharmacol. 2021,268:113591. doi: 10.1016/j.jep.2020.113591（中科院二区，IF=5.19）

6. Gao M^#, Lan J, Bao B, Yao W, Cao Y, Shan M, Cheng F, Chen P*, Zhang L*. Effects of carbonized process on quality control, chemical composition and pharmacology of Typhae Pollen: A review. J Ethnopharmacol. 2021,270:113774. doi: 10.1016/j.jep.2020.113774. （中科院二区，IF=5.19）

7.Peidong Chen^#, Yudan Cao, Beihua Bao, Li Zhang*, Anwei Ding.Antioxidant capacity of Typha angustifolia extracts and two active flavonoids,Pharm Biol. 2017 ,55(1):1283-1288. doi: 10.1080/13880209.2017.1300818..中科院三区，IF=1.92）

8.Peidong Chen^#, Shijia Liu^#, Guoliang Dai, Liyan Xie, Jie Xu, Ling Zhou, Wenzheng Ju*, Anwei Ding. Determination of typhaneoside in rat plasma by liquid chromatography–tandem mass spectrometry, J Pharm Biomed Anal. 2012,70:636-9. doi: 10.1016/j.jpba.2012.06.032.（中科院三区，IF=2.95）

9.Liu S^#, Dai G, Sun L, Sun B, Chen D, Zhu L, Wang Y, Zhang L, Chen P*, Zhou D*, Ju W*. Biotransformation and Metabolic Profile of Limonin in Rat Liver Microsomes, Bile, and Urine by High-Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry. J Agric Food Chem. 2018,66(40):10388-10393. doi: 10.1021/acs.jafc.8b02057.（中科院一区，IF=3,57）

10. Liu S^#, Wang Y, Liu H, Xu T, Wang MJ, Lu J, Guo Y, Chen W, Ke M, Zhou G, Lu Y*, Chen P*, Zhou W*. Serum lipidomics reveals distinct metabolic profiles for asymptomatic hyperuricemic and gout patients. Rheumatology (Oxford). 2022,61(6):2644-2651. doi: 10.1093/rheumatology/keab743.（中科院二区，IF=5.50）

科研项目

1.国家自然科学基金面上项目（81873001），基于VEGF-A通路PLCγ1-PI3K/Akt反馈机制的蒲黄炭化瘀止血炮制机理研究，2019/01-2022/12，主持，经费数57万，在研

2.南京中医药大学中药学一流学科培育项目（ZYXPY2024-003），中药炭药止血的科学内涵研究，2025/01-2030/12，主持，经费数30万，在研

3.国家自然科学基金面上项目（81573604），基于Na-K-ATP酶对津液“收敛固涩”探讨五味子“生熟异用”作用机制，2008/01-2010/12，参与，经费数60万，结题

4.国家自然科学基金青年项目（3701108），醋蒸五味子炮制机理的研究，2019/01-2022/12，参与，经费数23万，结题

5.中国药典会项目（项目编号：YD-108），蒲黄炭饮片质量标准研究，2009/01-2010/12，主持，经费数5万，结题

6.江苏省中医院管理局项目，蒲黄炭炮制机理研究，2007/01-2010/12，主持，经费数1万，结题。

7.南京中医药大学风险基金项目，抗溃疡性结肠炎创新中药新药的研制（CX201202)，2012/01-2014/12，主持，经费数10万，结题

代表性论文