魏丹丹

副教授

E-mail：wei.dandan@njucm.edu.cn

主要研究方向：

中药资源化学与综合利用、中药功效物质基础与效应评价

个人简介

1. Sha CY, Wei DD*, Xu WQ, Sun HZ, Yin YY, Su SL, Zhao M, Duan JA*. Zhujing Pill ameliorates age-related macular degeneration by regulating lipid metabolism, complement activation, and inflammatory responses: an integrated network pharmacology and metabolomics study. J Ethnopharmacol, 2026, 366: 121674.（中科院二区，IF=5.4）

2. Song YH, Wei DD*, Wang Q, Guo JM, Zhu Y, Shang EX, Duan JA*. Luteoloside mitigates premature age-related macular degeneration by suppressing p53-p21-Rb1 axis: Insights from transcriptomic analysis, serum metabolomics and gut microbiota analysis. J Pharm Biomed Anal. 2024 Sep 15; 248: 116296. doi: 10.1016/j.jpba.2024.116296. Epub 2024 Jun 13. PMID: 38878454.（中科院三区，IF=3.1）

3. Chen X#, Wei DD#, Lin M, Wang XS, Kang HJ, Ni L, Qian DW, Guo S*, Duan JA*. Comparative evaluation of four Lycium barbarum cultivars on NaIO3-induced retinal degeneration mice via multivariate statistical analysis. J Ethnopharmacol. 2024 May 10: 325: 117889. doi: 10.1016/j.jep.2024.117889. Epub 2024 Feb 8. PMID: 38336183.（中科院二区，IF=4.8）

4. Chang XW, Wei DD*, Su SL, Guo S, Qian SE, Yan H, Zhao M, Shang EX, Qian DW, Sun XD, Duan JA*. An integrated strategy for rapid discovery and prediction of nucleobases, nucleosides and amino acids as quality markers in different flowering stages of Flos Chrysanthemi using UPLC-MS/MS and FT-NIR coupled with multivariate statistical analysis. Microchem J. 2020, 153: 104500. doi: 10.1016/j.microc.2019.104500.（中科院二区，IF=4.9）

5. Wei DD#, Wang JS#, Duan JA*, Kong LY*. Metabolomic assessment of acute cholestatic injuries induced by thioacetamide and by bile duct ligation, and the protective effects of Huang-Lian-Jie-Du-Decoction. Front Pharmacol. 2018 May 8: 9: 458. doi: 10.3389/fphar.2018.00458. eCollection 2018. PMID: 29867467.（中科院二区，IF=4.4）

6. Wei DD, Wang JS*, Li MH, Guo PP, Dong G, Yang MH, Kong LY*. A pilot study of the onset of hepatic encephalopathy (OHE) in mice induced by thioacetamide and the protective effect of taurine by holistic metabolic characterization, Metabolomics, 2015, 11 (3): 559-570.（中科院三区，IF=3.5）

7. Wei DD#, Liao ST#, Wang JS*, Yang MH, Kong LY*. Cholestatic liver injury model of bile duct ligation and the protection of Huang-Lian-Jie-Du decoction by NMR metabolomic profling, RSC advances, 2015, 5 (81): 66200-66211.（中科院三区，IF=3.9）

8. Wei DD, Wang JS*, Kong LY*. Reversal effects of components from the fruits of Illicium simonsii on human adriamycin-resistant MCF-7 and 5-fluorouracil-resistant Bel7402 cells. Phytotherapy Research 2012, 26 (4): 562-567.（中科院二区，IF=6.1）

科研项目

1. 国家自然科学基金面上项目（82173965），菊花多元组分通过调控肠道菌群结构及内源性代谢改善年龄相关性黄斑变性作用机制研究，2022/01-2025/12，主持，55万，结题。

2. 国家自然科学基金联合基金项目（U21A20408），基于“肝-眼轴”的枸杞子及其复方防治青少年近视与年龄相关性黄斑变性的功效物质与生物学机制研究, 2022/01-2025/12，参与，260万, 结题。

3. 国家自然科学基金青年基金项目（81603273），基于代谢组学技术的菊叶平肝明目功效物质基础及作用机制研究，2017/01-2019/12，主持，17万，结题。

4. 江苏省中药资源产业化过程协同创新中心重点项目（ZDXM-3-15），菊非药用部位资源价值发现与产业化开发, 2016/01-2017/12，主持，30万, 结题。

代表性论文