姓名:苏联麟
职称:副教授、硕士生导师
E-mail:sll2020@njucm.edu.cn
主要研究方向:中药炮制机理与质量标准研究
个人简介
苏联麟,博士,副教授,民进会员。南京中医药大学药学院中药炮制教研室骨干教师,华润三九博士后;中华中医药学会中药炮制分会青年委员,世界中医药联合会中药饮片质量专业委员会理事,江苏省药学会中药药理专业委员会委员等。主要从事中药炮制机理及质量标准研究,包括中药质量标志物、代谢组学、肠道微生物组等。在国内外高水平期刊上发表论文50余篇,其中以第一/通讯作者于Food Chemistry等期刊发表高水平论文20余篇。担任Frontiers in Cellular and Infection Microbiology期刊专栏客座编委,STCM青年编委等。主持“国家自然科学青年基金项目”1项、省高校自然科学基金1项、企业委托课题1项及其他横向课题5项;主持安徽省博后基金1项;参与国家自然科学基金项目8项,其中国自然重点项目1项;参与国家重点研发计划(2018、2023年)2项,申请并获授权发明专利4项。
承担的主要科研项目
(1)国家自然科学基金委员会青年科学基金项目(82304723),基于糖组学及“粘蛋白O-聚糖/PRRs”双调控模式的五味子醋制增强涩肠止泻作用机制研究,2024-01-01 至 2026-12-31,主持,30万元,在研;
(2)(2)江苏省高等学校 基础科学(自然科学)研究面上项目(23KJB360008),基于“CAZymes-SCFAs-黏膜免疫”轴探究五味子醋制增强涩肠止泻作用机制,2023.7 至2025.7,主持,3万元,在研;
(3)华润三九医药股份有限公司,企业委托,4个配方颗粒制备工艺和标准研究,2021-08 至 2023-08,主持,76万元,结题;
(4)中国生物技术发展中心,国家重点研发计划,2023YFC3504200,中药饮片炒炙智能识别与生产控制技术研究,2023-11 至 2026-10,参与,2418.88万元,在研;
(5)国家自然科学基金委员会面上项目(82274241),从“豆豉后下”实现杀酶保苷/保肽的角度探讨栀子豉汤抗抑郁作用机制,2023-01-01 至 2026-12-31,参与,51万元,在研;
(6)国家自然科学基金委员会面上项目(82274096),基于生栀子泻温邪实火、炒栀子清郁热与脓毒症双向免疫调节特点探索栀子炮制机理与合理用药,2023-01-01 至 2026-12-31,参与,52万元,在研;
(7)国家自然科学基金委员会面上项目(82173975)基于整合证据链的郁金醋制增强疏肝止痛作用机制研究,2022-01-01 至 2025-12-31,参与,55万元,在研;
(8)国家自然科学基金委员会重点项目(82130116)蒙药巴格-塔日努(京大戟)等3种大戟属常用有毒药炮制减毒增效的共性机制研究,2022-01-01 至 2026-12-31,参与,290万元,在研;
(9)国家自然科学基金委员会面上项目(82074004),DASS-RTCA系统驱动“物质-效应-标准”三元关联的经典名方制剂当归补血汤的质量一致性评价研究,2021-01-01 至 2024-12-31,参与,55万元,结题;
(10)国家自然科学基金委员会,面上项目,81873008,基于肠道菌群介导的五味子醋制增强收敛止泻效应机制研究,2019-01-01 至 2022-12-31,参与,59万元,结题。
代表性论文
Zhang J, Gao T, Chen G, Liang Y, Nie X, Gu W, Li L, Tong H, Huang W, Lu T, Bian Z, Su L. Vinegar-processed Schisandra Chinensis enhanced therapeutic effects on colitis-induced depression through tryptophan metabolism. Phytomedicine, 2024, 135: 156057.(中科院一区,IF:6.7)
Lian-lin Su1; Xiaoman Li1; Zhi-jun Guo; Xiao-yan Xiao; Peng Chen; Jiu-ba Zhang; Chun-qin Mao; De Ji; Jing Mao; Bo Gao*; Tu-lin Lu*; Effects of different steaming times on the composition, structure and immune activity of Polygonatum Polysaccharide, Journal of Ethnopharmacology, 2023, 310: 116351. (中科院二区,IF:5.4)
Su L#; Mao C#; Wang X; Li L; Tong H; Mao J; Ji D*; Lu T*; Hao M; Huang Z; The anti-colitis effect of Schisandra chinensis polysaccharide is associated with the regulation of the composition and metabolism of gut microbiota, Frontiers in Cellular and Infection Microbiology, 2020,10: 519479.(中科院二区,IF:6.1)
Lianlin Su#; Jing Mao#; Min Hao; Tulin Lu*; Chunqin Mao*; De Ji; Huangjin Tong; Chenghao Fei; Integrated Plasma and Bile Metabolomics Based on an UHPLC-Q/TOF-MS and Network Pharmacology Approach to Explore the Potential Mechanism of Schisandra chinensis-Protection from Acute Alcoholic Liver Injury, Frontiers in pharmacology, 2020,10:1543.(中科院二区,IF:5.8)
Jiu-ba Zhang1; Bin Wang1; Yun-fei Zhang1; Yi Wu; Mingxuan Li; Ting Gao; Tu-lin Lu*; Zhen-hua Bian*; Lian-lin Su*; E-eye and FT-NIR combined with multivariate algorithms to rapidly evaluate the dynamic changes in the quality of Gastrodia elata during steaming process, Food Chemistry, 2024, 439:138148.(中科院一区,IF:8.8)
YuLi#;ChenghaoFei#; ChunqinMao; DeJi; JingwenGong; YuwenQin; LingyunQu; WeiZhang; ZhenhuaBian; LianlinSu*; TulinLu*; Physicochemical parameters combined flash GC e-nose and artificial neural network for quality and volatile characterization of vinegar with different brewing techniques, Food Chemistry, 2022, 374: 131658.(中科院一区,IF:9.2)
Lianlin Su† , Huangjin Tong† , Jiuba Zhang, Min Hao, Chenghao Fei, De Ji, Wei Gu, Zhenhua Bian, Chunqin Mao*, Tulin Lu*; Revealing the mechanism of raw and vinegar-processed Curcuma aromatica Salisb. [Zingiberaceae] regulates primary dysmenorrhea in rats via integrated metabolomics, Frontiers in pharmacology, 2022, 13:926291.(中科院二区,IF:5.98)
Tian Y, Shen X, Hu T, Liang Z, Ding Y, Dai H, Liu X, Lu T, Yin F, Shu Y, Guo Z, Su L*, Li L*. Structural analysis and blood-enriching effects comparison based on biological potency of Angelica sinensis polysaccharides. Front Pharmacol, 2024, 15: 1405342.(中科院二区,IF:4.4)
Chen P, Fei C, Fu R, Xiao X, Qin Y, Li X, Guo Z, Huang J, Ji D, Li L, Lu T*, Guo Q*, Su L*. Polygonati Rhizoma varieties and origins traceability based on multivariate data fusion combined with an artificial intelligence classification algorithm. Food chemistry, 2024, 460(Pt 1): 140350.(中科院一区,IF:8.8)
Xiao-yan Xiao #, Zhi-jun Guo #, Xiaoman Li, Peng Chen, Yu Li, Jiu-ba Zhang, Chun-qin Mao, De Ji, Lian-lin Su *, Bo Gao *, Tu-lin Lu *. Effects of wine processed Polygonatum polysaccharides on immunomodulatory effects and intestinal microecology in mice. Quality Assurance and Safety of Crops & Foods, 2023, 15(2): 161-174.(中科院三区,IF:4.4)
获得奖项与荣誉
1.世界中联中药饮片质量专委会优秀教学成果二等奖(2023年,1/4);
2.苏州市中西医结合学会中西医结合医学科学技术将二等奖(2024年,5/6)。
其他成果
一、专利
(1)陆兔林,毛春芹,娄悦,毛靖,赵晓莉,许金国,苏联麟,梅茜,皮文霞,苏雪蓉.一种鳖血晶及其制备方法和应用[P].ZL202211087679.3, 2023-08-08.
(2)陆兔林,毛春芹,徐祯,毛靖,苏联麟,李林,顾薇,季德,张科卫,王巧晗.一种能提高抗氧化活性的栀子花复合提取物及其应用[P].ZL202110577891.7,2023-01-31.
(3)毛春芹,陆兔林,费程浩,梅茜,苏联麟,季德,毛靖,顾薇,李昱,秦宇雯,李林,董佳佳.一种莪术提取物及其在制备防治冠心病药物中的应用[P].ZL202210507145.5,2023-12-26.
(4)陆兔林,苏联麟,毛春芹,季德,顾薇,李昱,王巧晗,毛靖.五味子多糖在制备治疗炎症性肠病药物或保健品中的应用[P].ZL202010428961.8,2021-08-17.
二、论著
(1)《便秘中西医诊疗实践》,中国协和医科大学出版社,2018,编委。