郑云枫
教授
E-mail:zyunfeng88@126.com
主要研究方向:
中药/天然药物活性成分、质量控制及产业化研究
个人简介

[1] Yixuan Wu, Jie Sun, Wenjie Xie, Simin Xue, Xinli Li, Jianming Guo, Jinjun Shan, Guoping Peng, Yunfeng Zheng*. Immunomodulation of Glycyrrhiza Polysaccharides In Vivo Based on Microbiome and Metabolomics Approaches. Foods. 2025;14(5):874. (二区,IF=5.1)

[2] Jie Sun, Yi-Xuan Wu, Xin-Li Li, Wen-Jie Xie, Qing-ping Xiong, Chang-xing Jiang, Shu-Wan Tang, Guo-Ping Peng, Yun-Feng Zheng*. Structural characteristics of a neutral Glycyrrhiza uralensis polysaccharide and its fermentation properties on the gut microbiota of immunocompromised rats in vivo and vitro. Frontiers in Nutrition.(二区,IF=5.1)

[3] Zhan, G. Z., Guo, X. Y., Qiu, Z. C., Cai, L. Y., Hu, Q., Gao, Y., Tang, S. W., Li, C. Y., Zheng, Y. F., & Peng, G. P. (2024). Rapid evaluation of the quality of Smilax glabra Roxb. using QADS based on FT-NIR combined with multiple intelligent algorithms. Food chemistry, 2024,453:139633. .(中科院一区,IF=8.8)

[4] Jiaojiao Lu , Chengbo Zheng , Simin Xue , Ye Gao , Guijin Chen , Chenxiao Shan, Ning Ding , Guoping Peng, Cunyu Li*, Yunfeng Zheng*. Comprehensive Comparison of Three Different Medicinal Parts of Eupatorium lindleyanum DC. Using the RRLC-Q-TOF-MS-Based Metabolic Profile and In Vitro Anti-Inflammatory Activity. Molecules 2024, 29, 3551.(中科院二区,IF=4.2)

[5] Li Song, Bao-Qing Yang, Wen-Jie Xie, Ye Gao, Chen-Xiao Shan, Guo-Ping Peng, Xiang-Yun Xie, Xiao-Li Gao*, Yun-Feng Zheng*. An efficient method for rapid screening of triterpenoid saponins in three Glycyrrhiza species using rapid resolution liquid chromatography quadrupole time-of-flight mass spectrometry combined with mass defect filtering [J]. Journal of Pharmaceutical and Biomedical Analysis, 2024, 246: 116213.(中科院三区,IF=3.4)

[6] Li Song, Xiang-Yun Xie, Jie Sun, Shen-Hui Huang, Xin-Liang Li, Guo-Ping Peng, Xiao-Li Gao, Yun-Feng Zheng*. Structural identification and comprehensive comparison of saponin-related impurities present in the three different compound glycyrrhizin tablets. Journal of Pharmaceutical and Biomedical Analysis, 2023,229: 115287(中科院三区,IF=3.4)

 [7] Yang Li, Shenhui Huang, Jie Sun, Weiping Duan, Cunyu Li, Guoping Peng, Yunfeng Zheng*. RRLC-QTOF/MS-Based Metabolomics Reveal the Mechanism of Chemical Variations and Transformations of Astragali Radix as a Result of the Roasting Process. Front. Chem., 2022, 10, 903168. (中科院三区,IF= 5.3)

[8]郑云枫,孙捷,段伟萍,李洋,陈丽红,陆兔林,李存玉,彭国平*. 光果甘草三萜皂苷类化学成分研究, 药学学报. 2021,56(01): 289-295.

[9] Yunfeng Zheng 1, Danyang Li1, Jie Sun, Jianming Cheng, Chuan Chai, Li Zhang*, Guoping Peng. Comprehensive Comparison of Two Color Varieties of Perillae Folium Using RRLC-Q/TOF-MS-Based Metabolic Profile and in Vivo / in Vitro Anti-Oxidative Activity. Journal of Agricultural and food chemistry. 2020, 68, 14684−14697(中科院一区,IF= 5.7)

[10] Rui Liu, Yong Huang, Haokun Xue, Yunfeng Zheng*, Yang Liu, Shuying Han, Min Yang, Yu Xie, Kaixuan Wang, Jin-ao Duan, Lingjun Li*. A strategy for identifying species-specific peptide biomarkers in deer-hide gelatin using untargeted and targeted mass spectrometry approaches. Analytica Chimica Acta, 2019,1092: 32-41. (中科院二区,IF= 5.7)

科研项目

[1]国家自然科学基金面上项目(81973482),基于肠道菌-SCFAs /GPCRs免疫通路研究甘草蜜炙增强补脾益气的效应机制,2020/01~2023/12,主持,55.00万,结题。

[2]国家青年自然科学基金面上项目(81373980),基于"QCAR/ 3D-QSAR"的甘草抗HBV肝损伤多靶导向作用研究,2012/01~2014/12,主持,23.00万,结题。

[3]新疆维吾尔自治区重大科技专项项目/子课题(2022A02013-3). 结合雌激素关键甾体/非甾体对照物质制备及质量标准提升研究. 2022/12~2025/12,主持,40.00万,在研.

[4]江苏省333工程“卡脖子”技术攻关人才项目. 常用大宗中药材甘草/丹参的资源综合利用. 2022/12,主持,20.00万,结题。

[5]新疆自治区重点研发计划项目/子课题(2020B03007-2),复方甘草酸苷片及原料药有关物质研究,2021/01~2023/12,主持,30.00万,结题。

[6]江苏省自然科学基金(SBK201123752),基于QCAR/3D-QSAR的甘草多靶点抗HBV肝损伤研究,2011/01~2013/12,主持,10.00万,结题。

[7]国家药典委员会,盐泽泻质量标准的研究,2009/01~2012/12,主持,3.00万,结题。

[8]中国药科大学/新药开发合作,11031颗粒新药临床前药学研究,2024/01~2026/12,主持,88.00万,在研。

[9]南京科领医药科技有限公司新药开发合作, KLN01颗粒新药临床前药学研究,2024/08~2026/08, 主持,130.00万,在研。

[10] 华润三九医药股份有限公司,仙连解毒颗粒新药研究, 2024.08-2029.07, 第二负责人,680.00万,在研

代表性论文

[1] Yixuan Wu, Jie Sun, Wenjie Xie, Simin Xue, Xinli Li, Jianming Guo, Jinjun Shan, Guoping Peng, Yunfeng Zheng*. Immunomodulation of Glycyrrhiza Polysaccharides In Vivo Based on Microbiome and Metabolomics Approaches. Foods. 2025;14(5):874. (二区,IF=5.1)

[2] Jie Sun, Yi-Xuan Wu, Xin-Li Li, Wen-Jie Xie, Qing-ping Xiong, Chang-xing Jiang, Shu-Wan Tang, Guo-Ping Peng, Yun-Feng Zheng*. Structural characteristics of a neutral Glycyrrhiza uralensis polysaccharide and its fermentation properties on the gut microbiota of immunocompromised rats in vivo and vitro. Frontiers in Nutrition.(二区,IF=5.1)

[3] Zhan, G. Z., Guo, X. Y., Qiu, Z. C., Cai, L. Y., Hu, Q., Gao, Y., Tang, S. W., Li, C. Y., Zheng, Y. F., & Peng, G. P. (2024). Rapid evaluation of the quality of Smilax glabra Roxb. using QADS based on FT-NIR combined with multiple intelligent algorithms. Food chemistry, 2024,453:139633. .(中科院一区,IF=8.8)

[4] Jiaojiao Lu , Chengbo Zheng , Simin Xue , Ye Gao , Guijin Chen , Chenxiao Shan, Ning Ding , Guoping Peng, Cunyu Li*, Yunfeng Zheng*. Comprehensive Comparison of Three Different Medicinal Parts of Eupatorium lindleyanum DC. Using the RRLC-Q-TOF-MS-Based Metabolic Profile and In Vitro Anti-Inflammatory Activity. Molecules 2024, 29, 3551.(中科院二区,IF=4.2)

[5] Li Song, Bao-Qing Yang, Wen-Jie Xie, Ye Gao, Chen-Xiao Shan, Guo-Ping Peng, Xiang-Yun Xie, Xiao-Li Gao*, Yun-Feng Zheng*. An efficient method for rapid screening of triterpenoid saponins in three Glycyrrhiza species using rapid resolution liquid chromatography quadrupole time-of-flight mass spectrometry combined with mass defect filtering [J]. Journal of Pharmaceutical and Biomedical Analysis, 2024, 246: 116213.(中科院三区,IF=3.4)

[6] Li Song, Xiang-Yun Xie, Jie Sun, Shen-Hui Huang, Xin-Liang Li, Guo-Ping Peng, Xiao-Li Gao, Yun-Feng Zheng*. Structural identification and comprehensive comparison of saponin-related impurities present in the three different compound glycyrrhizin tablets. Journal of Pharmaceutical and Biomedical Analysis, 2023,229: 115287(中科院三区,IF=3.4)

 [7] Yang Li, Shenhui Huang, Jie Sun, Weiping Duan, Cunyu Li, Guoping Peng, Yunfeng Zheng*. RRLC-QTOF/MS-Based Metabolomics Reveal the Mechanism of Chemical Variations and Transformations of Astragali Radix as a Result of the Roasting Process. Front. Chem., 2022, 10, 903168. (中科院三区,IF= 5.3)

[8]郑云枫,孙捷,段伟萍,李洋,陈丽红,陆兔林,李存玉,彭国平*. 光果甘草三萜皂苷类化学成分研究, 药学学报. 2021,56(01): 289-295.

[9] Yunfeng Zheng 1, Danyang Li1, Jie Sun, Jianming Cheng, Chuan Chai, Li Zhang*, Guoping Peng. Comprehensive Comparison of Two Color Varieties of Perillae Folium Using RRLC-Q/TOF-MS-Based Metabolic Profile and in Vivo / in Vitro Anti-Oxidative Activity. Journal of Agricultural and food chemistry. 2020, 68, 14684−14697(中科院一区,IF= 5.7)

[10] Rui Liu, Yong Huang, Haokun Xue, Yunfeng Zheng*, Yang Liu, Shuying Han, Min Yang, Yu Xie, Kaixuan Wang, Jin-ao Duan, Lingjun Li*. A strategy for identifying species-specific peptide biomarkers in deer-hide gelatin using untargeted and targeted mass spectrometry approaches. Analytica Chimica Acta, 2019,1092: 32-41. (中科院二区,IF= 5.7)

获得奖项与荣誉

[1]郑云枫(5/7); 超微粉碎技术在新型中药饮片加工过程中的创新及应用中国产学研创新成果奖, 2017(徐浩坤谢宇张丽艳彭国平郑云枫李孟林苗旭辉)

其他成果

专利

[1]郑云枫; 魏娟花; 彭国平 ; 一种综合利用甘草的提取制备方法, 2014-02-12, 中国, ZL 20121011534 7.1 (成果转化,50万元)

[2]郑云枫; 程建明; 丁宁; 彭国平 ; 一种从丹参水提醇沉物中制备水苏糖的方法, 2013-10-16, 中国, ZL201110122779.0 (成果转化,50万元)

[3]郑云枫; 陆睿寅; 彭国平; 杨敏 ; 一种具有抗皮肤癌作用的组合物及其制备方法与应用, 2020-7-24, 中国, ZL201810469779.X (专利)

[4] ; 一种鉴别红糖及其制品的方法, 2020-4-17, 中国, ZL201810467978.7 (专利)

[5]郑云枫; 彭国平; 李存玉 ; 一种野马追有效部位的制备方法, 2019-11-12, 中国, ZL 201610939296. 2 (专利)

专著/教材

[1]《解码中成药》,专著,2022年,编委

[2]《中药制药化学》,省级创新教材,2016年,编委

新药研发

[1]中药新药,KLN01颗粒(临床批件),2026年,药学负责人

[2]中药新药,1301-01颗粒(临床批件),2025年,药学负责人

[3]中药新药,AC591颗粒(临床批件),2021年,药学负责人

[4]中药新药,崩漏停颗粒(临床批件),2017年,药学负责人

[5]中药新药,蓟七注射剂(临床批件),2007年,药学负责人



南中医药学院南中医药学院学子南中医药学院研究生