1.王欣之,潘雨琦. 一种天然裂木脂素类成分衍生物DhpB及其应用. 中国发明专利申请, 公开号: CN119504718A, 公开日: 2025-02-25.(第一发明人)
2.王欣之等. 菊芋倍半萜内酯及其药用衍生物与在抗急性髓性白血病中的应用. 中国发明专利, 授权号: CN114315850, 授权公告日: 2022-03.(第一发明人)
3.王欣之等. 草胡椒素E或其衍生物及其用途. 中国发明专利, 授权号: CN107266431, 授权公告日: 2017-10.(第一发明人)

E-mail:xinzhiwang@njucm.edu.cn1.王欣之,潘雨琦. 一种天然裂木脂素类成分衍生物DhpB及其应用. 中国发明专利申请, 公开号: CN119504718A, 公开日: 2025-02-25.(第一发明人)
2.王欣之等. 菊芋倍半萜内酯及其药用衍生物与在抗急性髓性白血病中的应用. 中国发明专利, 授权号: CN114315850, 授权公告日: 2022-03.(第一发明人)
3.王欣之等. 草胡椒素E或其衍生物及其用途. 中国发明专利, 授权号: CN107266431, 授权公告日: 2017-10.(第一发明人)
1.国家自然科学基金面上项目,32074067,基于SUMO化修饰调控的中药石蝉草裂木脂素抗KRAS突变型肿瘤的作用机制研究,2021/01-2024/12,主持,55万,结题;
2.江苏省高校自然科学重大项目,24KJA360010,盐生中药甜瓜蒂Cucurbitacin B 抑制乳腺癌耐药肺转移的机制研究,2024/07-2027/07,主持,15万,在研;
3.江苏省高校自然科学重大项目,19KJA310006,菊芋倍半萜内酯抗白血病干细胞的机制及构效关系研究,时间: 2019/09-2022/09,主持,30万,结题;
4.江苏省自然科学基金面上项目,BK20181419,Heliangolides型倍半萜内酯选择性抗白血病干细胞的机制及构效关系研究,2018/07-2022/07,主持,10万,结题;
5.国家自然科学基金青年项目,81402812,基于分子对接技术的天然裂木脂素Peperomin E抗肿瘤靶标的寻找及结构优化研究,2015/01-2017/12,主持,23万,结题;
6.江苏省自然科学基金青年项目,BK20130954,天然产物Peperomin E诱导胃癌细胞凋亡的机制和结构修饰研究,2013/06-2016/06,20万元,主持,结题。
7.江苏省中医药科技发展计划项目,MS2025005,江苏盐生中药甜瓜蒂葫芦烷型三萜靶向调控中性粒细胞胞外捕获网抑制TNBC化疗耐药性肺转移的机制研究,2026/01-2028/12, 10万,主持,在研。
1.Yuqi Pan, Shengjie Hua, Ruolan Yang, Qinman He, Yan Xu, Zeyu Jiang, Xiaoyang Gong, Shurui Zhang, Xiao Wang, Hongli Yu, Hao Wu, Hongmei Wen, Pin Wang, Bo Hang, Xinzhi Wang*. A Covalent Molecular Glue Hijacks the E3 Ligase MKRN2 to Degrade the Ribosomal Protein RPS7 and Induce Synthetic Lethality in P53‐deficient NSCLC Cells. British Journal of Pharmacology, 2026, bph.70434. (中科院2区,IF=7.7,共通讯作者)
2.Jie Cao, Bingbing Liu, Sheng Li, Zhican Cheng, Kou Zhang, Yanqing Xu, Yuxin Gu, Min Zeng, Changli Shen, Xin Li, Ronglu Yu, Xiaobin Cui, Huimin Bian, Xingde Zhang, Hao Wu, Xinzhi Wang*, Hongli Yu. Euphorbia pekinensis Glycosphingolipids Disrupt Gut Motility and Fluid Balance via TRPA1 Activation in Enterochromaffin Cells. British Journal of Pharmacology, 2025, bph.70219. (中科院2区,IF=7.7,共通讯作者)
3.Qianqian Xu, Zeyu Jiang, Yuqi Pan, Sheng Li, Zehong Cao, Shengjie Hua, Ruolan Yang, Qinman He, Hao Wu, Hongmei Wen, Bo Hang, Hongli Yu, Xinzhi Wang*. Cucurbitacin B Stimulates PD-1 Immunotherapy Response in Malignant Breast Cancer by Covalent Targeting MTCH2. Phytomedicine, 2025, 145: 157017. (中科院1区,IF=8.3,共通讯作者)
4.Xinzhi Wang*, Yi Qu#, Qianqian Xu, Zeyu Jiang, Hang Wang, Binyan Lin, Zehong Cao, Yuqi Pan, Sheng Li, Yili Hu, Hui Yang, Li He, Hang Chang, Bo Hang, Hongmei Wen, Hao Wu, Jian-Hua Mao. NQO1 Triggers Neutrophil Recruitment and NET Formation to Drive Lung Metastasis of Invasive Breast Cancer. Cancer Research, 2024, 84(21): 3538–3555. (中科院1区,IF=16.6,共同第一作者)
5.Hui Yang#, Xinzhi Wang#, Adrián Blanco-Gómez, Li He, Natalia García-Sancha, Roberto Corchado-Cobos, Manuel Jesús Pérez-Baena, Alejandro Jiménez-Navas, Pin Wang, Jamie L. Inman, Antoine M. Snijders, David W. Threadgill, Allan Balmain, Hang Chang, Jesus Perez-Losada, Jian-Hua Mao. A Susceptibility Gene Signature for ERBB2-Driven Mammary Tumour Development and Metastasis in Collaborative Cross Mice. eBioMedicine, 2024, 106: 105260. (中科院1区,IF=10.8,共同第一作者)
6.Yin Feng, Yefan Han, Anni Hu, Yi Qu, Yili Hu, Hao Wu, Xinzhi Wang*, Li He*. Heliangin Acts as a Covalent Ligand of RPS2 That Disrupts Pre-rRNA Metabolic Processes in NPM1-Mutated Acute Myeloid Leukemia. Acta Pharmaceutica Sinica B, 2023, 13(2): 598–617. (中科院1区,IF=14.8,共通讯作者)
7.Anni Hu, Hang Wang, Qianqian Xu, Yuqi Pan, Zeyu Jiang, Sheng Li, Yi Qu, Yili Hu, Hao Wu, Xinzhi Wang*. A Novel CPT1A Covalent Inhibitor Modulates Fatty Acid Oxidation and CPT1A-VDAC1 Axis with Therapeutic Potential for Colorectal Cancer. Redox Biology, 2023, 68: 102959. (中科院1区,IF=10.7,通讯作者)
8.Yefan Han, Anni Hu, Yi Qu, Qianqian Xu, Hang Wang, Yin Feng, Yili Hu, Li He, Hao Wu, Xinzhi Wang*. Covalent Targeting the LAS1-NOL9 Axis for Selective Treatment in NPM1 Mutant Acute Myeloid Leukemia. Pharmacological Research, 2023, 189: 106700. (中科院2区,IF=10.5,通讯作者)
9.Hui Yang#, Xinzhi Wang#, Pin Wang, Li He, Suzyann F. Schick, Peyton Jacob, Neal Benowitz, Lara A. Gundel, Chi Zhu, Yankai Xia, Jamie L. Inman, Hang Chang, Antoine M. Snijders, Jian-Hua Mao, Bo Hang. Thirdhand Tobacco Smoke Exposure Increases the Genetic Background-Dependent Risk of Pan-Tumor Development in Collaborative Cross Mice. Environment International, 2023, 174: 107876. (中科院1区,IF=10.3,共同第一作者)
10.Xinzhi Wang, Ming Gao, Jiyun Zhang, Ying Ma, Wenshu Qu, Jingyu Liang, Hao Wu, Hongmei Wen. Peperomin E and Its Orally Bioavailable Analog Induce Oxidative Stress-Mediated Apoptosis of Acute Myeloid Leukemia Progenitor Cells by Targeting Thioredoxin Reductase. Redox Biology, 2019, 24: 101153. (中科院1区,IF=10.7,第一作者)
1.王欣之,潘雨琦. 一种天然裂木脂素类成分衍生物DhpB及其应用. 中国发明专利申请, 公开号: CN119504718A, 公开日: 2025-02-25.(第一发明人)
2.王欣之等. 菊芋倍半萜内酯及其药用衍生物与在抗急性髓性白血病中的应用. 中国发明专利, 授权号: CN114315850, 授权公告日: 2022-03.(第一发明人)
3.王欣之等. 草胡椒素E或其衍生物及其用途. 中国发明专利, 授权号: CN107266431, 授权公告日: 2017-10.(第一发明人)
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