刘睿

教授

E-mail：liurui@njucm.edu.cn

主要研究方向：

海洋药用生物资源研究与开发、中药动物药资源化学

个人简介

1. Wei YQ*, Ju MM, Zheng F, Wei S, Han SY, Lu SF, Liu R*, Wu H*.Cuttlebone-derived organic matrix: a facile periosteum substitute for bone regeneration. Advanced Functional Materials, 2023, 33(31): 2214095. (IF = 18.5)

2. Zheng BR, Shang J, Wei YQ, Tao QQ, Yin JZ, Kang A, Liu R*, Lian HZ*, Han SY*. Chemoproteomic profiling by bioorthogonal probes to reveal the novel targets of acrylamide in microglia. Journal of Hazardous Materials, 2025, 484(15): 136760. (IF = 12.2)

3. Han SY, Li ZH, Shi YT, Cui YS, Huang JF, Frost DC, Rey FE, Liu R*, Li LJ*. 11-plex DiLeu isobaric labeling enables quantitative assessment of brain region protein-association networks impacted by the gut microbiome. Analytical Chemistry, 2024, 96(9): 3870-3878. (IF = 6.8)

4. Liu R, Wei PL, Keller C, Orefice N, Shi YT, Li ZH, Huang JF, Cui YS, Frost, D, Han SY, Cross TW, Rey F, Li LJ*. Integrated label-free and 10-plex DiLeu isobaric tag quantitative methods for profiling changes in the mouse hypothalamic neuropeptidome and proteome: assessment of the impact of the gut microbiome. Analytical Chemistry, 2020, 92(20): 14021-14030. (IF = 6.8)

5. Xia HR, Liu X, Cai S, Chen SJ, Li S, Zhao M, Duan JA, Liu R*, Han SY*. Identification and application of species-specific peptide biomarkers from soft-shelled turtles (Pelodiscus sinensis) using post-translational modification detection-based peptidomics analysis. Food Chemistry, 2023, 419: 135983. (IF = 8.5)

6. Han SY, Yan ZY, Huang XZ, Cai S, Zhao M, Zheng YF, Liu X, Xu HK, Xie Y, Hou R, Duan JA*, Liu R*. Response boosting-based approach for absolute quantification of gelatin peptides using LC-MS/MS. Food Chemistry, 2022, 390: 133111. (IF = 8.5)

7. Han SY, Zhao KX, Cai S, Jiang MT, Huang XZ, Chen SJ, Li S, Zhao M, Duan JA*, Liu R*. Discovery of peptide biomarkers by label-free peptidomics for discrimination of horn gelatin and hide gelatin from Cervus nippon Temminck. Food Chemistry, 2021, 363: 130347. (IF = 8.5)

8. Zheng F, Ju MM, Lü YJ, Hua YQ, Yao WF, Wu H, Zhao M, Han SY, Wei YQ*, Liu R*. Carp scales derived double cross-linking hydrogels achieve collagen peptides sustained-released for bone regeneration. International Journal of Biological Macromolecules, 2024, 255, 128276. (IF = 7.7)

9. Wu WX, Tang JY, Bao WL, Feng QY, Zheng J, Hong M, Guo S, Zhu Y, Huang SY, Zhao M, Duan JA*, Liu R*. Thiols-rich peptide from water buffalo horn keratin alleviates oxidative stress and inflammation through co-regulating Nrf2/Hmox-1 and NF-κB signaling pathway. Free Radical Biology and Medicine, 2024, 223: 131-143. (IF = 7.1)

10. Liu R, Huang Y, Xu HK, Zheng YF, Liu Y, Han SY, Yang M, Xie Y, Wang KX, Duan JA, Li LJ*. A strategy for identifying species-specific peptide biomarkers in deer-hide gelatin using untargeted and targeted mass spectrometry approaches. Analytica Chimica Acta, 2019, 1092: 32-41. (IF = 5.7)

科研项目

1.国家自然科学基金面上项目（82474055），硫巯基化修饰介导的水牛角药效物质活化及其清热功效作用机制研究，2025/01-2028/12，主持，在研。

2.国家自然科学基金面上项目（81973450），基于“脑-肠轴”研究水牛角含巯基肽类物质产生清热/镇静功效的化学生物学机制，2020/01-2023/12，主持，结题。

3.国家自然科学基金青年基金（81202861），水牛角对发热生物标记物的干预及其效应物质基础研究，2013/01-2015/12，主持，结题。

4.江苏省自然科学基金面上项目（BK20241913），基于“QTRP-蛋白修饰谱”的水牛角活性硫基团作用靶点发现及其清热功效机制研究，2024/07/01-2027/06/30，主持，在研。

5.江苏现代农业产业单项技术研发项目（CX(22)3173），鱼鳞、鱼骨来源胶原肽的磷酸化、糖基化修饰关键技术研究及产品开发，2021/07-2024/06，主持，结题。

6.舟山科技局重大科技攻关项目（2023C13020），海洋源功效化妆品新原料开发应用研究，2023/10-2026/09，主持，在研。

代表性论文