王宇彤

副教授

E-mail：wangyutong@njucm.edu.cn

主要研究方向：

抗肿瘤新剂型研发

个人简介

1.Chenjie Xia, et al, Yutong Wang*, Zhipeng Chen*.An efficient brain delivery system co-loaded with multiple components of Salvia miltiorrhiza for synergistic treatment of ischemic stroke. Materials Today Bio. 2025, 34:102102.

2.WangYutong^#, Huo Yiming^#, et al. Engineered exosomes with enhanced stability and delivery efficiency for glioblastoma therapy. Journal of Controlled Release, 2024, 368: 170-183 (ESI高被引论文)

3. WangYutong^#, Huang Jinyu^#, et al. Extra virgin olive oil-based phospholipid complex/self-microemulsion enhances oral absorption of salvianolic acid B through inhibition of catechol-O-methyltransferase-mediated metabolism. International Journal of Pharmaceutics, 2022, 611: 121330.

4. Chen Xiao^#, Wang Yutong^#, et al. Quantitative Chemical Proteomics Reveals Resveratrol Inhibition of A549 Cell Migration Through Binding Multiple Targets to Regulate Cytoskeletal Remodeling and Suppress EMT. Frontiers in pharmacology, 2021, 12: 636213.

5.WangYutong^#, Li Huaning ^#, et al. Mucoadhesive Nanocrystal-in-Microspheres with High Drug Loading Capacity for Bioavailability Enhancement of Silybin, Colloids and Surfaces B: Biointerfaces, 2021, 198: 111461.

6.Chen Xiao^#, Wang Yutong^#, et al. Target identification of natural medicine with chemical proteomics approach: probe synthesis, target fishing and protein identification, Signal Transduction and Targeted Therapy, 2020, 5(1): 1-13.

7.XuLiu ^#, Wang Yutong ^#, et al. Morphological transformation enhances Tumor Retention by Regulating the Self-assembly of Doxorubicin-peptide Conjugates, Theranostics, 2020, 10(18): 8162-8178.

8.Wang Yutong ^#, Huang Liping ^#, et al. Electrostatic interactions between polyglutamic acid and polylysine yields stable polyion complex micelles for deoxypodophyllotoxin delivery, International Journal of Nanomedicine, 2017, 12: 7963-7977.

9.Huang Liping ^#, Wang Yutong ^#, et al. Efficient delivery of paclitaxel into ASGPR over-expressed cancer cells using reversibly stabilized multifunctional pullulan nanoparticles. Carbohydrate polymers, 2017, 159: 178-187.

10.Wang Yutong, Sun Ting, et al. Exenatide loaded PLGA microspheres for long-acting antidiabetic therapy: preparation, characterization, pharmacokinetics and pharmacodynamics, RSC Advances, 2016, 6(44): 37452-37462.

科研项目

1.国家自然科学基金面上项目（82473371），“一肽多效”工程化细胞膜仿生递药系统多靶点协同治疗三阴性乳腺癌的研究，2025/01-2028/12，49万元，主持

2.国家自然科学基金青年项目（81803456），载药外泌体诱导生成多能干细胞用于治疗AD的研究，2019/01-2021/12，21万元，主持

3.江苏省卫生健康委员会（Z2023063）高表达同源黏附蛋白外泌体的构建及其负载替莫唑胺用于脑胶质瘤的靶向治疗, 2024/01-2027/12, 5万元, 主持

4.国家重点研发计划“中医药现代化研究”重点专项子课题（2018YFC1706905），多元微小丸及高载药量技术的中药释药系统设计关键技术研究，2018/12-2021/11，150万元，参与（项目骨干）

5.江苏省重点研发计划社会发展项目（SBE2023780098），DNA纳米结构的设计与调控构建高效核酸递送系统研究，2023/07-2026/06，100万元，参与（项目骨干）

6.国家自然科学基金地区科学基金（82060780），彝药美洲大蠊多肽原位驻留长效递释系统的构建及抗溃疡性结肠炎作用研究，2021/01-2024/12，34万元，参与

7.横向：溃结安灌肠液医院自制制剂研发，2023/11-2025/12，50万元，主持

代表性论文