姓名:王若宁
职称:教授 博士研究生导师
E-mail:ruoningw@njucm.edu.cn
主要研究方向
脑靶向中药制剂的研究
个人简介
王若宁,博士,教授、博士研究生导师,博士后合作导师,校团委兼职副书记,中药制剂系副主任,江苏省中药高效给药系统工程技术研究中心行政主任。入选国家高层次青年人才计划,全国中医药青年国医精英,江苏省优青,江苏省“333高层次人才培养工程”、江苏省科协青年科技人才托举工程、中华中医药学会青年人才托举工程(A类),获江苏省青年颗粒学奖。
聚焦中药多组分脑靶向仿生递送系统的研究,主持国家自然科学基金(面上、青年)等国家级、省级、厅局级项目二十余项,以第一或通讯作者发表ACS Nano,Journal of Controlled Release(5篇),Bioactive Materials,Acta Pharmaceutica Sinica B(2篇),Nano Today,Nano Letters, Small, Biomaterials , Chemical Engineering Journal等高水平论文四十余篇,其中IF>10分20篇,多篇文章入选ESI高被引及封面文章;申请并公开国家专利14项,其中授权8项,PCT 1项。
现任世界中医药学会联合会经皮给药专业委员会理事、中国颗粒学会青年理事、中华中医药学会中药制剂分会委员、中药毒理学与安全性研究分会委员等,任《Asian Journal of Pharmaceutical Sciences》、中草药中英双刊、《南京中医药大学学报》等期刊青年编委,参编江苏省高等学校重点教材《工业药剂学》、《中药药剂学》等。
指导学生获江苏省优秀硕士学位论文(2人次),连续五年指导本科生获得省级优秀本科毕业论文一等奖、省级二等奖等,连续三年获得省级优秀毕业论文团队奖。作为第一指导教师指导学生荣获第十八届“挑战杯”全国大学生课外学术科技作品竞赛国赛二等奖、江苏省选拔赛一等奖和二等奖,第八届江苏省“互联网+”大学生创新创业大赛二等奖,入选第十六届全国大学生创新创业年会改革成果展示项目,受邀参加第十六届全国大学创新创业年会。
代表性论文
1. Jiwei Cui‡, Xue Wang‡, Jinge Li, Anran Zhu, Yingjiang Du, Wei Zeng, Yumiao Guo, Liuqing Di, Ruoning Wang*.Immune exosomes loading self-assembled nanomicelles traverse the blood-brain barrier for chemo-immunotherapy against glioblastoma.ACS Nano,2023, 17: 1464-1484
2. Ruoning Wang, Xiaohong Wang, Junsong Li, Liuqing Di, Jianping Zhou*, Yang Ding*. Lipoprotein-biomimetic nanostructure enables tumor-targeted penetration delivery for enhanced photo-gene therapy towards glioma. Bioactive Materials, 2022, 13: 286-299
3. Jiale Li, Hanwen Zhang, Yingyu Jiang, Nengjin Li, Anran Zhu, Yingjie Zhang, Kuanhan Feng, Wei Zeng, Liuqing Di*, Ruoning Wang*. The landscape of extracellular vesicles combined with intranasal delivery towards brain diseases. Nano Today, 2024,55: 102169
4. Jinge Li‡, Xiaohong Wang‡, Yumiao Guo‡, Yingjie Zhang, Anran Zhu, Wei Zeng, Liuqing Di, Ruoning Wang*. Ginsenoside Rg3-engineered exosomes as effective delivery platform for potentiated chemotherapy and photoimmunotherapy of glioblastoma. Chemical Engineering Journal, 2023, 471: 144692
5. Jiwei Cui, Yuanxin Xu, Haiyan Tu, Huacong Zhao, Honglan Wang, Liuqing Di, Ruoning Wang*. Gather wisdom to overcome barriers:Well-designed nano-drug delivery systems for treating gliomas. Acta Pharmaceutica Sinica B, 2022, 12: 1100-1125
6. Ruoning Wang‡*, Xue Wang‡, Huacong Zhao‡, Nengjin Li, Jiale Li, Hanwen Zhang, Liuqing Di*.Targeted delivery of hybrid nanovesicles for enhanced brain penetration to achieve synergistic therapy of glioma. Journal of Controlled Release, 2024, 365: 331-347
7. Ruoning Wang‡*, Xinru Zhang‡, Jianyu Huang‡, Kuanhan Feng, Yingjie Zhang, Jie Wu, Lei Ma, Anran Zhu, Liuqing Di*. Bio-fabricated nanodrugs with chemo-immunotherapy to inhibit glioma proliferation and recurrence. Journal of Controlled Release, 2023, 354: 572-587
8.Ruoning Wang‡*, Xiaohong Wang‡, Yuting Zhang, Huacong Zhao, Jiwei Cui, Junsong Li*, Liuqing Di*. Emerging prospects of extracellular vesicles for brain disease theranostics. Journal of Controlled Release, 2022, 341: 844-868
9. Ruoning Wang, Chenshuang Zhang, Junsong Li, Jinyu Huang, Yaw Opoku-Damoah, Bo Sun, Jianping Zhou, Liuqing Di*, Yang Ding*. Laser-triggered polymeric lipoproteins for precision tumor penetrating theranostics. Biomaterials. 2019, 221: 119413
10. Ruoning Wang*, Jinge Li, Xiaohong Wang, Yingjie Zhang, Anran Zhu, Kuanhan Feng, Junsong Li, Liuqing Di*. Personalized nanovaccines enhance lymph node accumulation and reprogram the tumor microenvironment for improved photodynamic immunotherapy. Nano Letters, 2024, 24: 7432-7442