洪泽
副教授
E-mail：300575@njucm.edu.cn
主要研究方向：
固有免疫信号通路的调控机制及药物开发
个人简介

1. Guo Hanli, Sun Minghui, Tao Mengdie, Zhu Juanjuan, Song Yulu, Chen Saihua, Guo Zhaoxi, Zhang Xiang, Hou Fajian, Sun Chunmeng, Ma Xiaonan, Hu Haiyang, Hong Ze, Wang Chen. MAVS signaling exacerbates chondrocytes extracellular matrix degradation in osteoarthritis. Cell Reports, 2026, 45(1), 116778. (Co-corresponding)

2. Zhang Lele, Lyu MA, Hong Ze, Sun Jing, Guo Lan, Hu Jiameng, Maimaiti Munire, Li Chenhui, Song Jinyi, Zhang Xiang, Yu Huangsha, Wang Chen, Wang Xuan, Hu Haiyang. Integrative Analyses Identify a cGAS-STING Pathway-Driven Signature with Context-Dependent Roles in Systemic Lupus Erythematosus. Advanced Science, 2026, e21560. (Co-first)

3. Yan Gao, Gucheng Xu, Munire Maimaiti, Saihua Chen, Xiang Zhang, Jiameng Hu, Chen Wang, Ze Hong, Haiyang Hu. Transcriptome-based characterization of 3’2’-cGAMP signaling mediated immune responses, Computational and Structural Biotechnology Journal, 2024, 23: 4131-4142. (Co-corresponding)

4. Ze Hong, Saihua Chen, Jing Sun, Dan Cheng, Hanli Guo, iahao Mei, Xiang Zhang, Munire Maimaiti, Haiping Hao, Peng Cao, Haiyang Hu, Chen Wang. STING signaling in islet macrophages impairs insulin secretion in obesity, SCIENCE CHINA Life Sciences, 2023, 67(2): 345-359.

5. Ze Hong, Jiahao Mei, Hanli Guo, Juanjuan Zhu, Chen Wang. Intervention of cGAS‒STING signaling in sterile inflammatory diseases, Journal of Molecular Cell Biology, 2022, 14(2): mjac005.

6. Ze Hong, Jiahao Mei, Chenhui Li, Guohui Bai, Munire Maimaiti, Haiyang Hu, Wenying Yu, Li Sun, Lele Zhang, Dan Cheng, Yixian Liao, Senlin Li, Yanping You, Hongbin Sun, Jing Huang, Xing Liu, Judy Lieberman, Chen Wang. STING inhibitors target the cyclic dinucleotide binding pocket, Proceedings of National Academy of Sciences, 2021, 118(24): e2105465118.

7. Ze Hong, Tianchi Ma, Xing Liu, Chen Wang. cGAS-STING pathway: post-translational modifications and functions in sterile inflammatory diseases, The FEBS Journal, 2021, 289(20): 6187-6208.

8. Jiaqian Liang, Ze Hong, Boyue Sun, Zhaoxi Guo, Chen Wang, Juanjuan Zhu. The Alternatively Spliced Isoforms of Key Molecules in the cGAS-STING Signaling Pathway. Frontiers in Immunology. 2021. (Co-first)

9. Senlin Li, Ze Hong, Zhe Wang, Fei Li, Jiahao Mei, Lulu Huang, Xiwen Lou, Simeng Zhao, Lihua Song, Wei Chen, Qiang Wang, Heng Liu, Yanni Cai, Huansha Yu, Huimin Xu, Guangzhi Zeng, Quanyi Wang, Juanjuan Zhu, Xing Liu, Ninghua Tan, Chen Wang. The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING, Cell reports, 2018, 25: 3405-3421. (Co-first)

科研项目

1.南京中医药大学中药制药过程控制与智能制造技术全国重点实验室，开放课题项目，NZYSKL250101，靶向ZBP1中药活性物质发现及在SLE疾病中的药理作用研究，2025/06至2027/06，20万元，在研, 主持；

2.国家自然科学基金, 面上项目, 82473930, 新型STING蛋白抑制剂干预系统性红斑狼疮疾病的机制研究, 2025/01 至 2028/12，48万元，在研，主持；

3.国家自然科学基金，青年科学基金项目，82204408，SAVI疾病相关STING突变体小分子抑制剂的作用机制与功能研究，2023/01至2025/12，主持，30万元，结题；

4.中国药科大学多靶标天然药物全国重点实验室，开放课题项目，SKLNMKF202308，固有免疫调控代谢重编程的新靶标与先导化合物发现，2023/09至 2025/08，10万元，结题，主持；

5.中国博士后科学基金特别资助（站前），2019TQ0356，靶向STING蛋白的小分子抑制剂开发及药效评价，2019/07至2021/12，主持，18万元，结题。

代表性论文

1. Guo Hanli, Sun Minghui, Tao Mengdie, Zhu Juanjuan, Song Yulu, Chen Saihua, Guo Zhaoxi, Zhang Xiang, Hou Fajian, Sun Chunmeng, Ma Xiaonan, Hu Haiyang, Hong Ze, Wang Chen. MAVS signaling exacerbates chondrocytes extracellular matrix degradation in osteoarthritis. Cell Reports, 2026, 45(1), 116778. (Co-corresponding)

2. Zhang Lele, Lyu MA, Hong Ze, Sun Jing, Guo Lan, Hu Jiameng, Maimaiti Munire, Li Chenhui, Song Jinyi, Zhang Xiang, Yu Huangsha, Wang Chen, Wang Xuan, Hu Haiyang. Integrative Analyses Identify a cGAS-STING Pathway-Driven Signature with Context-Dependent Roles in Systemic Lupus Erythematosus. Advanced Science, 2026, e21560. (Co-first)

3. Yan Gao, Gucheng Xu, Munire Maimaiti, Saihua Chen, Xiang Zhang, Jiameng Hu, Chen Wang, Ze Hong, Haiyang Hu. Transcriptome-based characterization of 3’2’-cGAMP signaling mediated immune responses, Computational and Structural Biotechnology Journal, 2024, 23: 4131-4142. (Co-corresponding)

4. Ze Hong, Saihua Chen, Jing Sun, Dan Cheng, Hanli Guo, iahao Mei, Xiang Zhang, Munire Maimaiti, Haiping Hao, Peng Cao, Haiyang Hu, Chen Wang. STING signaling in islet macrophages impairs insulin secretion in obesity, SCIENCE CHINA Life Sciences, 2023, 67(2): 345-359.

5. Ze Hong, Jiahao Mei, Hanli Guo, Juanjuan Zhu, Chen Wang. Intervention of cGAS‒STING signaling in sterile inflammatory diseases, Journal of Molecular Cell Biology, 2022, 14(2): mjac005.

6. Ze Hong, Jiahao Mei, Chenhui Li, Guohui Bai, Munire Maimaiti, Haiyang Hu, Wenying Yu, Li Sun, Lele Zhang, Dan Cheng, Yixian Liao, Senlin Li, Yanping You, Hongbin Sun, Jing Huang, Xing Liu, Judy Lieberman, Chen Wang. STING inhibitors target the cyclic dinucleotide binding pocket, Proceedings of National Academy of Sciences, 2021, 118(24): e2105465118.

7. Ze Hong, Tianchi Ma, Xing Liu, Chen Wang. cGAS-STING pathway: post-translational modifications and functions in sterile inflammatory diseases, The FEBS Journal, 2021, 289(20): 6187-6208.

8. Jiaqian Liang, Ze Hong, Boyue Sun, Zhaoxi Guo, Chen Wang, Juanjuan Zhu. The Alternatively Spliced Isoforms of Key Molecules in the cGAS-STING Signaling Pathway. Frontiers in Immunology. 2021. (Co-first)

9. Senlin Li, Ze Hong, Zhe Wang, Fei Li, Jiahao Mei, Lulu Huang, Xiwen Lou, Simeng Zhao, Lihua Song, Wei Chen, Qiang Wang, Heng Liu, Yanni Cai, Huansha Yu, Huimin Xu, Guangzhi Zeng, Quanyi Wang, Juanjuan Zhu, Xing Liu, Ninghua Tan, Chen Wang. The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING, Cell reports, 2018, 25: 3405-3421. (Co-first)

获得奖项与荣誉
其他成果

1.孙宏斌；王琛；尤燕平；孙立；洪泽；潘燕红；隋齐邦；臧永军；袁浩亮；温小安；许庆龙；柳军；酰胺类化合物及其作为STING抑制剂的医药用途，2021-02-26，中国，ZL 2020 1 1074409. X (专利)

2.王琛；洪泽；余文颖；孙宏斌；梅家豪；李晨辉；刘星；孙立；柳军；苯磺酰胺类化合物的医药用途 及其药物组合物, 2020-11-11, 中国, ZL202011070259.5 (专利)



南中医药学院南中医药学院学子南中医药学院研究生