学术讲座--The Creation and Immolation of Drug-Bearing Tubular Supramolecular Polymers
发布时间:2017-12-08 浏览次数:

报告人:Associate Professor Honggang Cui

时间:1211(周一)上午8:30-10:00

地点:图书馆305

Brief Biosketch Honggang Cui received a Bachelor’s degree in Polymer Materials Science and Engineering from the Beijing University of Chemical Technology in 1999, a Master’s degree in Materialogy/Chemical Engineering from Tsinghua University in 2002, and a PhD degree in Materials Science and Engineering from the University of Delaware in 2007. He was a Postdoctoral Fellow between 2007 and 2010 in the department of Materials Science and Engineering and the Institute for BioNanotechnology in Medicine at Northwestern University. He joined the Department of Chemical and Biomolecular Engineering and Institute for NanoBiotechnology at the Johns Hopkins University (JHU) as Assistant Professor in 2010 and was promoted to Associate Professor with Tenure in 2017. He serves as the Director for Graduate Admissions in the Department of Chemical and Biomolecular Engineering, and holds joint appointments in the Department of Material Science and Engineering, the Department of Oncology and Sidney Kimmel Comprehensive Cancer Center, and the Center for Nanomedicine of Wilmer Eye Institute at the JHU

Abstract: Supramolecular polymers are dynamic one-dimensional assemblies with a high degree of internal order and well-defined surface chemistry. The reversible nature of supramolecular polymers provides unique properties that expand the functional space of classical covalent polymers. The polymerization and depolymerization are the key features for a broad range of biomedical applications. In this presentation, I will discuss the distinct formation and immolation pathways of tubular supramolecular polymers crafted by self-assembly of therapeutic agents. In the polymerization process, the rationally designed drug amphiphile monomers first assemble into filaments mediated by the π-π stacking among the drug moieties, followed by the slow evolution into nanotubes. Upon dilution or under mild sonication, these supramolecular nanotubes, however, would undergo fragmentation into short ones, instead of depolymerizing in a reversible pathway. I will also discuss the use of these drug-bearing supramolecular polymers as universal carriers for imaging and therapeutic agents in both in vitro and in vivo settings. In the end, as Director of Graduate Admissions, I am happy to discuss the evaluation criteria for admitting Ph.D. students into our Chemical and Biomolecular Engineering graduate program in JHU.